Comparison of completely versus incompletely excised cutaneous squamous cell carcinomas.

نویسندگان

  • P Ang
  • A W H Tan
  • C L Goh
چکیده

INTRODUCTION This is a retrospective case series of cutaneous squamous cell carcinomas (SCCs) which were incompletely excised in National Skin Centre, Singapore from 1991 to 1995. This study compared the characteristics of completely excised versus incompletely excised cutaneous SCCs. MATERIALS AND METHODS All patients with histologically confirmed SCCs were traced from computerised medical database and information regarding patient profile, tumour characteristics, surgical treatment and outcome were collated. All patients were recalled for clinical examination and documentation of cure. Completely excised and incompletely excised SCCs were compared with regards to the patient and tumour characteristics. RESULTS There were 57 patients with 63 SCCs who were treated with surgical excision over the 5-year period. Fifty were recalled for physical examination. There were 30 males and 27 females and their mean age was 83.3 years. All except 1 were Chinese of Fitzpatrick skin type 4. One-third of patients had daily or weekly sun exposure in the past and 21.1% had occupational sun exposure; 3.5% had prior arsenic exposure and 3.5% were previously treated with radiotherapy for other malignancies. The mean duration of SCCs was 18.7 months; 7.9% of patients had multiple SCCs and 15.9% had underlying actinic keratoses. The mean diameter of the tumours was 1.97 cm and nearly half were located on the head and neck. All the SCCs were primary and localised to the skin; 84.1% of them were completely excised with a 4 to 6 mm margin. Incompletely excised SCCs were associated with the male sex, larger tumours and tumours on the genitals and lower limbs. CONCLUSION In our experience, the tumour clearance rate is 84.1% following conventional excision. Incomplete excision is associated with male sex, larger tumours and those on the genitals and lower limbs.

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Value of CD10 Expression in Differentiating Cutaneous Basal from Squamous Cell Carcinomas and Basal Cell Carcinoma from Trichoepithelioma

Background: In addition to the well-defined histological criteria for squamous cell carcinoma (SCC) and basal cell carcinoma (BCC), immunohistochemical techniques can be used in difficult cases for their differentiation. As differential diagnosis between trichoepithelioma (TE) and BCC is sometimes difficult for the clinician and the pathologist, CD10 may be a useful marker for definite diagnosi...

متن کامل

Comparative evaluation of the frequency of myofibroblasts between oral and cutaneous squamous cell carcinomas

Introduction: Differentiation of fibroblasts to myofibroblasts is an initial and very important event in tumor genesis. Myofibroblasts produce proteinases that stimulate invasion in cancers. Due to the more malignant potential of oral squamous cell carcinoma (OSCC) compared to cutaneous squamous cell carcinoma (CSCC) , the aim of the present study was to compare myofibroblasts between OSCC and ...

متن کامل

Immunohistochemical expression of CD10 in cutaneous basal and squamous cell carcinomas

 Background: Non-melanoma skin cancer is the most common malignant tumor in humans. The role of ultraviolet radiation is well-known in the pathogenesis of basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). CD10 is a zinc-dependent metallopeptidase known as common acute lymphoblastic leukemia antigen (CALLA). Although CD10 expression has been investigated in some cutaneous tu...

متن کامل

Incidence of incomplete excision in surgically treated basal cell carcinomas and identification of the related risk factors

Background: Surgery is the most frequent treatment modality for basal cell carcinoma but in spite of its high cure rate, the frequency of incomplete excision varies widely (0.7-50%) among dermatologic centers. Our case series was designed to determine the frequency of incompletely excised basal cell carcinoma and the related risk factors. Methods: A total of 1424 basal cell carcinoma (1040 pati...

متن کامل

Treatment of conjunctival squamous cell carcinoma with topical 5-fluorouracil.

AIM To evaluate the efficacy of topical 5-fluorouracil (5-FU) alone, without concurrent surgery or radiotherapy, for the treatment of conjunctival squamous cell carcinoma. METHODS Eight patients affected by conjunctival squamous cell carcinoma (three recurrent cases, three incompletely excised, and two untreated cases) were treated with 1% 5-FU eye drops. Topical 1% 5-FU was administered four...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

عنوان ژورنال:
  • Annals of the Academy of Medicine, Singapore

دوره 33 1  شماره 

صفحات  -

تاریخ انتشار 2004